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KANAMYCIN MONOSULFATE

kanamycin sulfate mixture of components A

CAS: 70560-51-9;25389-94-0;133-92-6

Molecular Formula: C18H38N4O15S

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KANAMYCIN MONOSULFATE - Names and Identifiers

Name kanamycin sulfate mixture of components A
Synonyms Kanamycin Sulfate
Kanamycin Monosulfate
KANAMYCIN MONOSULFATE
Kanamycin Sulfate Usp
Kanamycin Sulfate Salt
KANAMYCIN MONO SULPHATE
Kanamycin Mono Sulphate
Kanamycin Sulfate White
C18H36-37N4-5O10-11H2SO4
KANAMYCIN MONOSULFATE SALT
Kanamycin Monosulfate Salt
Kanmycin MonosulfateSulfate
Kanamycin Solution Hybri-Max
kanamycin sulfate mixture of components A
KANAMYCIN SULFATE MIXTURE OF COMPONENTS A,B AND C
2-(Aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol sulfate
(1S,2R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-α-D-glucopyranoside sulfate (salt)
(1R,2S,3S,4R,6R)-4,6-Diamino-3-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 6-amino-6-deoxy-α-L-galactopyranoside sulfate (salt)
(2S,3S,4R,5S,6S)-2-(aminomethyl)-6-[(1R,2S,3S,4R,6R)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol,sulfuric acid
CAS 70560-51-9
25389-94-0
133-92-6
EINECS 684-844-0
InChI InChI=1/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5-,6+,7-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18+;/m1./s1

KANAMYCIN MONOSULFATE - Physico-chemical Properties

Molecular FormulaC18H38N4O15S
Molar Mass582.58
Melting Point250℃
Boling Point943.2°C at 760 mmHg
Specific Rotation(α)117.5 ° (C=1, H2O)
Flash Point524.2°C
Solubility It is soluble in water and almost insoluble in chloroform or ether.
Vapor Presure0mmHg at 25°C
Appearancegrayish white powder
Colorwhite to off-white
BRN3874279
Storage Condition2-8°C
MDLMFCD00070253
Physical and Chemical Properties

Melting Point:> 250
solubility: H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8 ℃. Stable at 37 °c for 5 days.
storage conditions: 2-8 ℃
WGK Germany:3
RTECS:NZ3225030

UseFor the treatment of esophagitis, antral gastritis, bacillary dysentery and digestive tract infections

KANAMYCIN MONOSULFATE - Risk and Safety

Risk Codes61 - May cause harm to the unborn child
Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S53 - Avoid exposure - obtain special instructions before use.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany3
RTECSNZ3225030

KANAMYCIN MONOSULFATE - Upstream Downstream Industry

Raw MaterialsZinc sulphate
Ferrous sulfate
Ammonium chloride
Sodium nitrate
Ethyl Alcohol

KANAMYCIN MONOSULFATE - Reference

Reference
Show more
1. Wei Qinglan, Zhang Jipei, Ren Tao, et al. Drug Sensitivity Analysis of Escherichia coli from waterfowl in Guangdong province [J]. Heilongjiang Journal of Animal Husbandry and Veterinary Medicine, 2015, 000(012):180-181.
2. Zhang Jipei, Wei Qinglan, Tan Hualong, etc. Study on drug resistance and aminoglycoside resistance genes of Escherichia coli isolated from waterfowl in Guangdong province [J]. Progress in animal medicine, 2016, 37(005):42-46.
3. Liu Minfang, Cao mengrui, Li Rongxu, etc. Isolation, identification and drug sensitivity analysis of salmonella from waterfowl in some areas of Guangdong province [J]. Heilongjiang Journal of Animal Science and Veterinary Medicine, 2018(10).
4. Li Yan, Xia Boyuan, Li Xin, Ding Xu, Wang Wentian, Yu Weixian. Role of Nrf2 in liver injury induced by periodontitis in rats [J]. Journal of Oral Science Research, 2020,36(12):1113-1116.
5. Zhang Xiu, Tan Zhenghuai, Ma Miao Miao, Li Xiaoyuan, Zhou Xue. Preparation and activity evaluation of thrombolytic enzyme from douchi AprE9912D [J]. Chinese herbal medicine, 2021,52(02):367-377.
6. Pei Jia, Tong Bu, Xinyu Sun, Yingnan Liu, Jingen Liu, Qinzhi Wang, Yuhang Shui, Shuwen Guo, Li Wang,A sensitive and selective approach for detection of tetracyclines using fluorescent molybdenum disulfide nanoplates,Food Chemistry,Volume 297,2019,124
7. Ming Lu, Chenyang Cao, Feng Wang, Guocong Liu,A polyethyleneimine reduced graphene oxide/gold nanocubes based electrochemical aptasensor for chloramphenicol detection using single-stranded DNA-binding protein,Materials & Design,Volume 199,2021,109409,
8. Yu Liu, Jin-Wen Shangguan, Bi-Yi Xu, Xiao-Dong Yu Jing-Juan Xu, and Hong-Yuan ChenAnalytical Chemistry 2020 92 (3), 2722-2730DOI: 10.1021/acs.analchem.9b04934
9. [IF=2.896] Bao-Shan He et al."Electrochemical aptasensor based on aptamer-complimentary strand conjugate and thionine for sensitive detection of tetracycline with multi-walled carbon nanotubes and gold nanoparticles amplification."Anal Methods-Uk. 2018 Feb;10(7):783
10. [IF=7.963] Tao Wang et al."Quantitative characterization of toxicity interaction within antibiotic-heavy metal mixtures on Chlorella pyrenoidosa by a novel area-concentration ratio method."Sci Total Environ. 2021 Mar;762:144180
11. [IF=7.514] Pei Jia et al."A sensitive and selective approach for detection of tetracyclines using fluorescent molybdenum disulfide nanoplates."Food Chem. 2019 Nov;297:124969
12. [IF=6.986] Yu Liu et al."Abnormal Liquid Chasing Effect in Paper Capillary Enables Versatile Gradient Generation on Microfluidic Paper Analytical Devices."Anal Chem. 2020;92(3):2722-2730
13. [IF=4.821] Wenjuan Wang et al."Efficient fabrication of ratiometric fluorescence imprinting sensors based on organic-inorganic composite materials and highly sensitive detection of oxytetracycline in milk."Microchem J. 2020 Sep;157:105053
14. [IF=10.588] Yingying Zha et al."Size-dependent enhancement on conjugative transfer of antibiotic resistance genes by micro/nanoplastics."J Hazard Mater. 2022 Jun;431:128561

KANAMYCIN MONOSULFATE - Introduction

odorless; hygroscopic. The pH of the aqueous solution of the 12% of kanamycin monosulfate is 7 · 0-9 · 0; the pH of the aqueous solution of the 30% of kanamycin sulfate is 6 · 0-8 · 0.
Last Update：2022-10-16 17:28:05

KANAMYCIN MONOSULFATE - Role and use

This product is aminoglycoside broad-spectrum antibiotics, antibacterial spectrum and neomycin similar. The main Gram-negative bacteria such as Escherichia coli, Klebsiella, Proteus, Pneumonia Bacillus, Enterobacter aerogenes and Shigella caused by serious infection, the drug resistance of Staphylococcus aureus also has a good antibacterial effect. Clinically, it is mainly used for pulmonary infection, urinary tract infection, biliary tract infection, sepsis and abdominal infection caused by sensitive bacteria, and the latter two are often used in combination with other antibacterial drugs. Can also be used for other antibiotic resistance and sensitive to this product of Staphylococcus aureus infection. For the treatment of tuberculosis, this product can be used as a second-line drug.

principle

  1. This product mainly binds to the 30S subunit of bacterial ribosomes and inhibits bacterial protein synthesis. In recent years, the number of resistant strains has increased significantly, because some bacteria produce aminoglycoside inactivation enzymes, so that the loss of antibacterial activity. Kanamycin and streptomycin, neomycin have complete cross-resistance, and other aminoglycosides may have some cross-resistance.
  2. This product mainly binds to the 30S subunit of bacterial ribosomes and inhibits bacterial protein synthesis.
Last Update：2024-04-10 22:29:15

KANAMYCIN MONOSULFATE - Dosage and usage

  1. adult dosage: intramuscular injection or intravenous infusion, once 0.5g, once every 12 hours; Or according to body weight once 7.5mg/kg, once every 12 hours, adult daily dosage should not exceed 1.5g, treatment is not easy to exceed 14 days. Patients over 50 years of age should be appropriately reduced.
  2. Children's usual dosage: intramuscular injection or intravenous drip, according to the weight of 15-25mg/kg a day, divided into two doses.
  3. dosage when renal function decreases: creatinine clearance 50-90mg/min with 60-90% of the normal dose, once every 12 hours (normal dose is 7.5mg/kg each time, once every 12 hours); Creatinine clearance 10-50mg/min with 30-70% of the normal dose, once every 12-18 hours; Creatinine clearance <10mg/min with 20-30% of the normal dose, every 24-48 hours.
Last Update：2024-04-10 22:29:15

KANAMYCIN MONOSULFATE - Pharmacology and Toxicology

This product mainly binds to the 30S subunit unit of bacterial ribosome and inhibits the synthesis of bacterial protein.

Last Update：2024-04-10 22:43:14

KANAMYCIN MONOSULFATE - Reference Information

Use for the treatment of esophagitis, antral gastritis, bacillary dysentery and gastrointestinal infections
Last Update：2024-04-09 21:32:08
KANAMYCIN MONOSULFATE
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 70560-51-9
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Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Featured ProductsMultiple SpecificationsSpot supply
Product Name: Kanamycin sulfate Visit Supplier Webpage Request for quotation
CAS: 25389-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Multiple SpecificationsSpot supply
Product Name: Kanamycin Impurity 8 Visit Supplier Webpage Request for quotation
CAS: 70560-51-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: kanamycin sulfate mixture of components A Request for quotation
CAS: 25389-94-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: KANAMYCIN MONOSULFATE Request for quotation
CAS: 25389-94-0
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
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KANAMYCIN MONOSULFATE
Raw Materials for KANAMYCIN MONOSULFATE
Zinc sulphate
Ferrous sulfate
Ammonium chloride
Sodium nitrate
Ethyl Alcohol
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